Hypocalcemia in Animals: Causes, Symptoms, and Management

Commonly referred to as “milk fever” in cattle intended for beef or “eclampsia” in canine cases, hypocalcemia has a relatively reduced level of calcium in the bloodstream. While still susceptible to the development of eclampsia, although they remain hypocalcemic, pregnant females and those who are nursing are especially prone to hypocalcemia. Being well informed, farmers, veterinary professionals, and dog owners alike must learn everything about hypocalcemia so that early, effective life-saving therapy may be provided.

What is Hypocalcemia in Animals?

Calcium is required for numerous bodily processes in animals, such as:

  • Muscle contraction
  • Nerve transmission
  • Heart function
  • Blood clotting

In the event of blood calcium deficiency to a certain level, animals develop muscular, neurological, and systemic dysfunction. Hypocalcemia is either acute or chronic, and if left untreated, it can be fatal.

Hydropericardium

Commonly Affected Species

Dairy Cattle

  • Disease name: Milk Fever (Parturient Paresis)
  • Timing: Typically occurs within 72 hours post-calving
  • Cause: Unexpected calcium requirement for milk production

Dogs (Small Breeds)

  • Disease name: Eclampsia or Puerperal Tetany
  • Timing: Usually within the first 2–3 weeks of lactation
  • Cause: Excessive demand for calcium from suckling puppies

Muscular Dystrophy 

Sheep and Goats

  • As in cows, it commonly occurs in late pregnancy or early lactation

Cats (rare)

  • It may be seen in lactating queens, but is rare

Causes of Hypocalcemia in Animals

  • Excessive milk production with insufficient dietary calcium
  • Dietary imbalance between calcium and phosphorus
  • Vitamin D deficiency (impacting calcium absorption)
  • Over-supplementation of calcium pre-partum (which dampens natural calcium-regulating mechanisms)
  • Impaired nutrition in pregnancy or lactation

Goat Injection Chart

Signs of Hypocalcemia in Animals

Signs vary between animals, but typically include:

General Signs

  • Muscle trembling
  • Weakness or stiffness
  • Restlessness or agitation
  • Panting or raised respiratory rate
  • Poor coordination (ataxia)
  • Hypothermia (low temperature)

In Dairy Cattle (Milk Fever)

  • Stumbling gait
  • Downer cow (cannot stand)
  • Cold extremities and ears
  • Dilated eyes
  • Decreased rumen motility
  • Coma or death without treatment

Bovine Ephemeral Fever

In Dogs (Eclampsia)

  • Restlessness, panting
  • Pacing or whining
  • Muscle twitching
  • Seizures in advanced cases
  • Quick progress if left untreated

Diagnosis

Veterinarians diagnose hypocalcemia by:

  • Clinical presentation
  • Laboratory tests (measuring ionized and total calcium)
  • Review of diet, pregnancy/lactation stage, and animal history

Treatment

Emergency Treatment

  • Intravenous calcium (usually calcium borogluconate)
  • Slow injection to prevent cardiac complications
  • Heart rate and rhythm monitoring during treatment

Artificial Insemination (AI) 

Supportive Care

  • Heat (particularly in cold climates)
  • Fluids, nutrition, and nursing care

Long-Term Management

  • Oral calcium supplementation for mild disease or prevention
  • Dietary modification: ensuring the correct calcium-phosphorus ratio
  • Vitamin D supplementation (under veterinary advice)

Prevention

Prevention is always better than a cure, particularly in production animals.

Coriza

In Livestock

  • Pre-partum dietary management: low calcium intake before calving to activate natural calcium mobilization
  • Balanced minerals: particularly calcium, phosphorus, and magnesium
  • Close monitoring of high-risk animals during the time of parturition

In Dogs and Cats

  • Don’t over-supplement calcium in pregnancy
  • Offer a balanced, high-quality diet appropriate to the life stage
  • Monitor lactating animals for prodromal signs

Veterinary Surgery

Final Thoughts

Hypocalcemia is a significant but potentially life-threatening disease in animals. Either operate a few milk cows or raise a litter of puppies, knowing the instructions and realizing that the disease can be the difference. Most animals recover well and can return to their normal activities with prompt veterinary attention and proper food.

If you suspect hypocalcemia in any of your animals, call your veterinarian right away — minutes count.

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